diff --git a/app/scrcpy.1 b/app/scrcpy.1
index cf8dfa7f..1c0c0f7a 100644
--- a/app/scrcpy.1
+++ b/app/scrcpy.1
@@ -258,10 +258,14 @@ LAlt, LSuper or RSuper toggle the capture mode, to give control of the mouse bac
 Also see \fB\-\-keyboard\fR.
 
 .TP
-.BI "\-\-mouse\-bind " xxxx
+.BI "\-\-mouse\-bind " xxxx[:xxxx]
 Configure bindings of secondary clicks.
 
-The argument must be exactly 4 characters, one for each secondary click (in order: right click, middle click, 4th click, 5th click).
+The argument must be one or two sequences (separated by ':') of exactly 4 characters, one for each secondary click (in order: right click, middle click, 4th click, 5th click).
+
+The first sequence defines the primary bindings, used when a mouse button is pressed alone. The second sequence defines the secondary bindings, used when a mouse button is pressed while the Shift key is held.
+
+If the second sequence of bindings is omitted, then it is the same as the first one.
 
 Each character must be one of the following:
 
@@ -272,7 +276,7 @@ Each character must be one of the following:
  - 's': trigger shortcut APP_SWITCH
  - 'n': trigger shortcut "expand notification panel"
 
-Default is 'bhsn' for SDK mouse, and '++++' for AOA and UHID.
+Default is 'bhsn:++++' for SDK mouse, and '++++:bhsn' for AOA and UHID.
 
 
 .TP
diff --git a/app/src/cli.c b/app/src/cli.c
index 08a4aa3f..9dd49538 100644
--- a/app/src/cli.c
+++ b/app/src/cli.c
@@ -493,11 +493,17 @@ static const struct sc_option options[] = {
     {
         .longopt_id = OPT_MOUSE_BIND,
         .longopt = "mouse-bind",
-        .argdesc = "xxxx",
+        .argdesc = "xxxx[:xxxx]",
         .text = "Configure bindings of secondary clicks.\n"
-                "The argument must be exactly 4 characters, one for each "
-                "secondary click (in order: right click, middle click, 4th "
-                "click, 5th click).\n"
+                "The argument must be one or two sequences (separated by ':') "
+                "of exactly 4 characters, one for each secondary click (in "
+                "order: right click, middle click, 4th click, 5th click).\n"
+                "The first sequence defines the primary bindings, used when a "
+                "mouse button is pressed alone. The second sequence defines "
+                "the secondary bindings, used when a mouse button is pressed "
+                "while the Shift key is held.\n"
+                "If the second sequence of bindings is omitted, then it is the "
+                "same as the first one.\n"
                 "Each character must be one of the following:\n"
                 " '+': forward the click to the device\n"
                 " '-': ignore the click\n"
@@ -505,7 +511,8 @@ static const struct sc_option options[] = {
                 " 'h': trigger shortcut HOME\n"
                 " 's': trigger shortcut APP_SWITCH\n"
                 " 'n': trigger shortcut \"expand notification panel\"\n"
-                "Default is 'bhsn' for SDK mouse, and '++++' for AOA and UHID.",
+                "Default is 'bhsn:++++' for SDK mouse, and '++++:bhsn' for AOA "
+                "and UHID.",
     },
     {
         .shortopt = 'n',
@@ -2095,24 +2102,46 @@ parse_mouse_binding(char c, enum sc_mouse_binding *b) {
 }
 
 static bool
-parse_mouse_bindings(const char *s, struct sc_mouse_bindings *mb) {
-    if (strlen(s) != 4) {
-        LOGE("Invalid mouse bindings: '%s' (expected exactly 4 characters from "
-             "{'+', '-', 'b', 'h', 's', 'n'})", s);
+parse_mouse_binding_set(const char *s, struct sc_mouse_binding_set *mbs) {
+    assert(strlen(s) >= 4);
+
+    if (!parse_mouse_binding(s[0], &mbs->right_click)) {
+        return false;
+    }
+    if (!parse_mouse_binding(s[1], &mbs->middle_click)) {
+        return false;
+    }
+    if (!parse_mouse_binding(s[2], &mbs->click4)) {
+        return false;
+    }
+    if (!parse_mouse_binding(s[3], &mbs->click5)) {
         return false;
     }
 
-    if (!parse_mouse_binding(s[0], &mb->right_click)) {
+    return true;
+}
+
+static bool
+parse_mouse_bindings(const char *s, struct sc_mouse_bindings *mb) {
+    size_t len = strlen(s);
+    // either "xxxx" or "xxxx:xxxx"
+    if (len != 4 && (len != 9 || s[4] != ':')) {
+        LOGE("Invalid mouse bindings: '%s' (expected 'xxxx' or 'xxxx:xxxx', "
+             "with each 'x' being in {'+', '-', 'b', 'h', 's', 'n'})", s);
         return false;
     }
-    if (!parse_mouse_binding(s[1], &mb->middle_click)) {
+
+    if (!parse_mouse_binding_set(s, &mb->pri)) {
         return false;
     }
-    if (!parse_mouse_binding(s[2], &mb->click4)) {
-        return false;
-    }
-    if (!parse_mouse_binding(s[3], &mb->click5)) {
-        return false;
+
+    if (len == 9) {
+        if (!parse_mouse_binding_set(s + 5, &mb->sec)) {
+            return false;
+        }
+    } else {
+        // use the same bindings for Shift+click
+        mb->sec = mb->pri;
     }
 
     return true;
@@ -2408,10 +2437,18 @@ parse_args_with_getopt(struct scrcpy_cli_args *args, int argc, char *argv[],
                 LOGW("--forward-all-clicks is deprecated, "
                      "use --mouse-bind=++++ instead.");
                 opts->mouse_bindings = (struct sc_mouse_bindings) {
-                    .right_click = SC_MOUSE_BINDING_CLICK,
-                    .middle_click = SC_MOUSE_BINDING_CLICK,
-                    .click4 = SC_MOUSE_BINDING_CLICK,
-                    .click5 = SC_MOUSE_BINDING_CLICK,
+                    .pri = {
+                        .right_click = SC_MOUSE_BINDING_CLICK,
+                        .middle_click = SC_MOUSE_BINDING_CLICK,
+                        .click4 = SC_MOUSE_BINDING_CLICK,
+                        .click5 = SC_MOUSE_BINDING_CLICK,
+                    },
+                    .sec = {
+                        .right_click = SC_MOUSE_BINDING_CLICK,
+                        .middle_click = SC_MOUSE_BINDING_CLICK,
+                        .click4 = SC_MOUSE_BINDING_CLICK,
+                        .click5 = SC_MOUSE_BINDING_CLICK,
+                    },
                 };
                 break;
             case OPT_LEGACY_PASTE:
@@ -2701,26 +2738,36 @@ parse_args_with_getopt(struct scrcpy_cli_args *args, int argc, char *argv[],
     }
 
     // If mouse bindings are not explictly set, configure default bindings
-    if (opts->mouse_bindings.right_click == SC_MOUSE_BINDING_AUTO) {
-        assert(opts->mouse_bindings.middle_click == SC_MOUSE_BINDING_AUTO);
-        assert(opts->mouse_bindings.click4 == SC_MOUSE_BINDING_AUTO);
-        assert(opts->mouse_bindings.click5 == SC_MOUSE_BINDING_AUTO);
+    if (opts->mouse_bindings.pri.right_click == SC_MOUSE_BINDING_AUTO) {
+        assert(opts->mouse_bindings.pri.middle_click == SC_MOUSE_BINDING_AUTO);
+        assert(opts->mouse_bindings.pri.click4 == SC_MOUSE_BINDING_AUTO);
+        assert(opts->mouse_bindings.pri.click5 == SC_MOUSE_BINDING_AUTO);
+        assert(opts->mouse_bindings.sec.right_click == SC_MOUSE_BINDING_AUTO);
+        assert(opts->mouse_bindings.sec.middle_click == SC_MOUSE_BINDING_AUTO);
+        assert(opts->mouse_bindings.sec.click4 == SC_MOUSE_BINDING_AUTO);
+        assert(opts->mouse_bindings.sec.click5 == SC_MOUSE_BINDING_AUTO);
+
+        static struct sc_mouse_binding_set default_shortcuts = {
+            .right_click = SC_MOUSE_BINDING_BACK,
+            .middle_click = SC_MOUSE_BINDING_HOME,
+            .click4 = SC_MOUSE_BINDING_APP_SWITCH,
+            .click5 = SC_MOUSE_BINDING_EXPAND_NOTIFICATION_PANEL,
+        };
+
+        static struct sc_mouse_binding_set forward = {
+            .right_click = SC_MOUSE_BINDING_CLICK,
+            .middle_click = SC_MOUSE_BINDING_CLICK,
+            .click4 = SC_MOUSE_BINDING_CLICK,
+            .click5 = SC_MOUSE_BINDING_CLICK,
+        };
 
         // By default, forward all clicks only for UHID and AOA
         if (opts->mouse_input_mode == SC_MOUSE_INPUT_MODE_SDK) {
-            opts->mouse_bindings = (struct sc_mouse_bindings) {
-                .right_click = SC_MOUSE_BINDING_BACK,
-                .middle_click = SC_MOUSE_BINDING_HOME,
-                .click4 = SC_MOUSE_BINDING_APP_SWITCH,
-                .click5 = SC_MOUSE_BINDING_EXPAND_NOTIFICATION_PANEL,
-            };
+            opts->mouse_bindings.pri = default_shortcuts;
+            opts->mouse_bindings.sec = forward;
         } else {
-            opts->mouse_bindings = (struct sc_mouse_bindings) {
-                .right_click = SC_MOUSE_BINDING_CLICK,
-                .middle_click = SC_MOUSE_BINDING_CLICK,
-                .click4 = SC_MOUSE_BINDING_CLICK,
-                .click5 = SC_MOUSE_BINDING_CLICK,
-            };
+            opts->mouse_bindings.pri = forward;
+            opts->mouse_bindings.sec = default_shortcuts;
         }
     }
 
diff --git a/app/src/input_manager.c b/app/src/input_manager.c
index 2cc34afa..d3c94d03 100644
--- a/app/src/input_manager.c
+++ b/app/src/input_manager.c
@@ -708,7 +708,7 @@ sc_input_manager_process_touch(struct sc_input_manager *im,
 }
 
 static enum sc_mouse_binding
-sc_input_manager_get_binding(const struct sc_mouse_bindings *bindings,
+sc_input_manager_get_binding(const struct sc_mouse_binding_set *bindings,
                              uint8_t sdl_button) {
     switch (sdl_button) {
         case SDL_BUTTON_LEFT:
@@ -744,11 +744,18 @@ sc_input_manager_process_mouse_button(struct sc_input_manager *im,
         im->mouse_buttons_state &= ~button;
     }
 
+    SDL_Keymod keymod = SDL_GetModState();
+    bool ctrl_pressed = keymod & KMOD_CTRL;
+    bool shift_pressed = keymod & KMOD_SHIFT;
+
     if (control && !paused) {
         enum sc_action action = down ? SC_ACTION_DOWN : SC_ACTION_UP;
 
+        struct sc_mouse_binding_set *bindings = !shift_pressed
+                                              ? &im->mouse_bindings.pri
+                                              : &im->mouse_bindings.sec;
         enum sc_mouse_binding binding =
-            sc_input_manager_get_binding(&im->mouse_bindings, event->button);
+            sc_input_manager_get_binding(bindings, event->button);
         assert(binding != SC_MOUSE_BINDING_AUTO);
         switch (binding) {
             case SC_MOUSE_BINDING_DISABLED:
@@ -812,9 +819,6 @@ sc_input_manager_process_mouse_button(struct sc_input_manager *im,
         im->mouse_buttons_state |= button;
     }
 
-    SDL_Keymod keymod = SDL_GetModState();
-    bool ctrl_pressed = keymod & KMOD_CTRL;
-    bool shift_pressed = keymod & KMOD_SHIFT;
     bool change_vfinger = event->button == SDL_BUTTON_LEFT &&
             ((down && !im->vfinger_down && (ctrl_pressed ^ shift_pressed)) ||
              (!down && im->vfinger_down));
diff --git a/app/src/options.c b/app/src/options.c
index 5556d1f9..5eec6427 100644
--- a/app/src/options.c
+++ b/app/src/options.c
@@ -24,10 +24,18 @@ const struct scrcpy_options scrcpy_options_default = {
     .keyboard_input_mode = SC_KEYBOARD_INPUT_MODE_AUTO,
     .mouse_input_mode = SC_MOUSE_INPUT_MODE_AUTO,
     .mouse_bindings = {
-        .right_click = SC_MOUSE_BINDING_AUTO,
-        .middle_click = SC_MOUSE_BINDING_AUTO,
-        .click4 = SC_MOUSE_BINDING_AUTO,
-        .click5 = SC_MOUSE_BINDING_AUTO,
+        .pri = {
+            .right_click = SC_MOUSE_BINDING_AUTO,
+            .middle_click = SC_MOUSE_BINDING_AUTO,
+            .click4 = SC_MOUSE_BINDING_AUTO,
+            .click5 = SC_MOUSE_BINDING_AUTO,
+        },
+        .sec = {
+            .right_click = SC_MOUSE_BINDING_AUTO,
+            .middle_click = SC_MOUSE_BINDING_AUTO,
+            .click4 = SC_MOUSE_BINDING_AUTO,
+            .click5 = SC_MOUSE_BINDING_AUTO,
+        },
     },
     .camera_facing = SC_CAMERA_FACING_ANY,
     .port_range = {
diff --git a/app/src/options.h b/app/src/options.h
index f840a989..5ec809f0 100644
--- a/app/src/options.h
+++ b/app/src/options.h
@@ -165,13 +165,18 @@ enum sc_mouse_binding {
     SC_MOUSE_BINDING_EXPAND_NOTIFICATION_PANEL,
 };
 
-struct sc_mouse_bindings {
+struct sc_mouse_binding_set {
     enum sc_mouse_binding right_click;
     enum sc_mouse_binding middle_click;
     enum sc_mouse_binding click4;
     enum sc_mouse_binding click5;
 };
 
+struct sc_mouse_bindings {
+    struct sc_mouse_binding_set pri;
+    struct sc_mouse_binding_set sec; // When Shift is pressed
+};
+
 enum sc_key_inject_mode {
     // Inject special keys, letters and space as key events.
     // Inject numbers and punctuation as text events.
diff --git a/doc/mouse.md b/doc/mouse.md
index 1c62ddd0..ec4aea63 100644
--- a/doc/mouse.md
+++ b/doc/mouse.md
@@ -80,21 +80,37 @@ process like the _adb daemon_).
 
 ## Mouse bindings
 
-By default, with SDK mouse, right-click triggers BACK (or POWER on) and
-middle-click triggers HOME. In addition, the 4th click triggers APP_SWITCH and
-the 5th click expands the notification panel.
+By default, with SDK mouse:
+ - right-click triggers BACK (or POWER on)
+ - middle-click triggers HOME
+ - the 4th click triggers APP_SWITCH
+ - the 5th click expands the notification panel
 
-In AOA and UHID mouse modes, all clicks are forwarded by default.
+The secondary clicks may be forwarded to the device instead by pressing the
+<kbd>Shift</kbd> key (e.g. <kbd>Shift</kbd>+right-click injects a right click to
+the device).
 
-The shortcuts can be configured using `--mouse-bind=xxxx` for any mouse mode.
-The argument must be exactly 4 characters, one for each secondary click:
+In AOA and UHID mouse modes, the default bindings are reversed: all clicks are
+forwarded by default, and pressing <kbd>Shift</kbd> gives access to the
+shortcuts (since the cursor is handled on the device side, it makes more sense
+to forward all mouse buttons by default in these modes).
+
+The shortcuts can be configured using `--mouse-bind=xxxx:xxxx` for any mouse
+mode. The argument must be one or two sequences (separated by `:`) of exactly 4
+characters, one for each secondary click:
 
 ```
---mouse-bind=xxxx
+                  .---- Shift + right click
+       SECONDARY  |.--- Shift + middle click
+        BINDINGS  ||.-- Shift + 4th click
+                  |||.- Shift + 5th click
+                  ||||
+                  vvvv
+--mouse-bind=xxxx:xxxx
              ^^^^
              ||||
-             ||| `- 5th click
-             || `-- 4th click
+   PRIMARY   ||| `- 5th click
+  BINDINGS   || `-- 4th click
              | `--- middle click
               `---- right click
 ```
@@ -111,8 +127,18 @@ Each character must be one of the following:
 For example:
 
 ```bash
-scrcpy --mouse-bind=bhsn  # the default mode with SDK mouse
-scrcpy --mouse-bind=++++  # forward all clicks (default for AOA/UHID)
-scrcpy --mouse-bind=++bh  # forward right and middle clicks,
-                          # use 4th and 5th for BACK and HOME
+scrcpy --mouse-bind=bhsn:++++  # the default mode for SDK mouse
+scrcpy --mouse-bind=++++:bhsn  # the default mode for AOA and UHID
+scrcpy --mouse-bind=++bh:++sn  # forward right and middle clicks,
+                               # use 4th and 5th for BACK and HOME,
+                               # use Shift+4th and Shift+5th for APP_SWITCH
+                               # and expand notification panel
+```
+
+The second sequence of bindings may be omitted. In that case, it is the same as
+the first one:
+
+```bash
+scrcpy --mouse-bind=bhsn
+scrcpy --mouse-bind=bhsn:bhsn  # equivalent
 ```